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Multidrug and carbapenem-resistant Acinetobacter baumannii infections: Factors associated with mortality

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dc.contributor.authorHernández-Torres, A
dc.contributor.authorGarcía-Vázquez, E
dc.contributor.authorGómez, K
dc.contributor.authorCanteras, M
dc.contributor.authorRuíz, J
dc.contributor.authorYagüe, G
dc.contributor.departmentGenética y Microbiología
dc.date.accessioned2024-01-30T09:07:48Z
dc.date.available2024-01-30T09:07:48Z
dc.date.issued2011-11-16
dc.description.abstractBackground and objective: To analyse factors related to mortality and influence of antibiotic treatment on outcome in patients with nosocomial infection due to multidrug and carbapenem-resistant Acinetobacter baumannii (MDR-C AB). Patients and methods: Observational and prospective study of a cohort of adult patients with MDR-C AB infection. Data collection from clinical records was done according to a standard protocol (January 2007 through June 2008). Patients with MDR-C AB infection were identified by review of results of microbiology cultures from the hospital microbiology laboratory. Epidemiological and clinical variables and predictors of mortality were analysed. Results: 24 out of 101 cases were considered colonizations and 77 infections (27 bacteraemia); global mortality in infected patients was 49% (18 cases with bacteraemia and 20 with no bacteraemia). In the multivariate analysis, including the 77 cases of infection, the prognosis factors associated with mortality were age (OR 1.09; 95% CI 1.02-1.2), McCabe 1 (OR 33.98; 95% CI 4.33-266.85), bacteraemia (OR 9.89; 95% CI 1.13-86.13), inadequate empiric treatment (OR 16.7; 95% CI 2.15-129.79), and inadequate definitive treatment (OR 26.29; 95% CI 1.45-478.19). In the multivariate analysis including the 57 cases of infection with adequate definitive treatment, the prognosis factors associated with mortality were McCabe 1 (OR 24.08; 95% CI 3.67-157.96) and monotherapy versus combined treatment (OR 7.11; 95% CI 1.63-30.99). Conclusions: Our cohort of patients with MDR-C AB infection is characterised by a very high mortality (49%); the severity of patients and inadequate treatment or monotherapy are statistically associated with mortality.es
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dc.identifier.citationMed Clin (Barc). 2012 May 26 138(15):650-655
dc.identifier.doihttps://doi.org/10.1016/j.medcli.2011.06.024
dc.identifier.issn0025-7753
dc.identifier.urihttp://hdl.handle.net/10201/138111
dc.languagespaes
dc.relation"Sin financiación externa a la Universidad".es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAcinetobacter baumannii resistance-carbapenemses
dc.titleMultidrug and carbapenem-resistant Acinetobacter baumannii infections: Factors associated with mortalityes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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