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Morphological characteristics and peptidergic innervation in the carotid body of spontaneously hypertensive rats

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dc.contributor.authorTakahashi, Masahiro
dc.contributor.authorMatsuda, Hideki
dc.contributor.authorHayashida, Yoshiaki
dc.contributor.authorYamamoto, Yoshio
dc.contributor.authorTsukuda, Mamoru
dc.contributor.authorKusakabe, Tatsumi
dc.date.accessioned2016-03-09T15:25:34Z
dc.date.available2016-03-09T15:25:34Z
dc.date.issued2011
dc.description.abstractWe examined morphological characteristics of the carotid body of spontaneously hypertensive rats (SHR), those of age-matched normotensive Wistar rats (NWR), and age-matched genetically comparable Wistar Kyoto rats (WKY). We examined the distribution and abundance of four different regulatory neuropeptides: substance P (SP), calcitonin gene-related peptide (CGRP), vasoactive intestinal polypeptide (VIP), and neuropeptide Y (NPY) in the carotid bodies of these three strains of rats. The carotid bodies of SHR were larger than those of NWR and WKY. The values of the long axis of the carotid bodies of SHR were significantly larger (1.3 times) than those of NWR and WKY. In the carotid bodies of SHR, the percentage of relatively large vessels was similar to that of the carotid bodies of WKY, although the carotid bodies themselves were significantly larger than in WKY. The density of VIP varicose fibers in the carotid bodies of SHR was lower than in the carotid bodies of WKY, although the density of SP, CGRP and NPY fibers was similar to that of the carotid bodies of NWR and WKY. These findings suggested that VIP was unrelated to enlargement of the carotid body of SHR, but it might modify the sensitivity of chemoreceptors in the carotid body.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/48287
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 26, nº 3 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCarotid bodyes
dc.subject.other636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticoses
dc.titleMorphological characteristics and peptidergic innervation in the carotid body of spontaneously hypertensive ratses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº3 (2011)