Publication: Morphological characteristics
and peptidergic innervation in the carotid
body of spontaneously hypertensive rats
Authors
Takahashi, Masahiro ; Matsuda, Hideki ; Hayashida, Yoshiaki ; Yamamoto, Yoshio ; Tsukuda, Mamoru ; Kusakabe, Tatsumi
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We examined morphological characteristics
of the carotid body of spontaneously hypertensive rats
(SHR), those of age-matched normotensive Wistar rats
(NWR), and age-matched genetically comparable Wistar
Kyoto rats (WKY). We examined the distribution and
abundance of four different regulatory neuropeptides:
substance P (SP), calcitonin gene-related peptide
(CGRP), vasoactive intestinal polypeptide (VIP), and
neuropeptide Y (NPY) in the carotid bodies of these
three strains of rats. The carotid bodies of SHR were
larger than those of NWR and WKY. The values of the
long axis of the carotid bodies of SHR were significantly
larger (1.3 times) than those of NWR and WKY. In the
carotid bodies of SHR, the percentage of relatively large
vessels was similar to that of the carotid bodies of WKY,
although the carotid bodies themselves were
significantly larger than in WKY. The density of VIP
varicose fibers in the carotid bodies of SHR was lower
than in the carotid bodies of WKY, although the density
of SP, CGRP and NPY fibers was similar to that of the
carotid bodies of NWR and WKY. These findings
suggested that VIP was unrelated to enlargement of the
carotid body of SHR, but it might modify the sensitivity
of chemoreceptors in the carotid body.
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