Publication: Histopathology of the spleen in non-Hodgkin´s lymphoma
Authors
van Krieken, J.H.J.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The human spleen has several different
lymphoid compartments, which may be preferentially
involved by non-Hodgkin's lymphomas. Low grade Bcell
lymphomas tend to involve the compartments of the
spleen where their normal physiological counterparts
are found. High grade B-cell lymphomas grow more
destructively without respecting lymphoid compartments.
T-cell lymphomas involve mainly the T-cell areas, but
may also involve follicles and the red pulp. Since
non-Hodgkin's lymphomas can be regarded as clonal
proliferations of lymphocytes frozen at a stage in
differentiation, one posible conclusion is that low grade
lymphomas are governed by normal homing mechanisms.
High grade lymphomas may have lost their homing
properties.
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Citation
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