Publication: Autophagy and the regulation of the immune response
Authors
Macián, Fernando ; Valdor Alonso, Rut
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Publisher
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DOI
https://doi.org/10.1016/j.phrs.2012.10.003
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info:eu-repo/semantics/article
Description
© 2012 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Pharmacological Research. To access the final edited and published work see https://doi.org/10.1016/j.phrs.2012.10.003
Abstract
Autophagy is a highly conserved mechanism of lysosomal-mediated protein degradation that plays
a crucial role in maintaining cellular homeostasis by recycling amino acids, reducing the amount
of damaged proteins and regulating protein levels in response to extracellular signals. In the last
few years specific functions for different forms of autophagy have been identified in many tissues
and organs. In the Immune System, autophagy functions range from the elimination infectious
agents and the modulation of the inflammatory response, to the selection of antigens for
presentation and the regulation of T cell homeostasis and activation. Here, we review the recent
advances that have allowed us to better understand why autophagy is a crucial process in the
regulation of the innate and adaptive immune responses.
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Citation
Pharmacological Research, 2012, Vol. 66, Issue 6, pp. 475-483
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/