Publication: VEGF-A/VEGF-B/VEGF-C expressions in non- hereditary, non-metastatic phaeochromocytoma
Authors
Abe, Ichiro ; Islam, Farhadul ; Lo, Chung Yau ; Liew, Victor ; Pillai, Suja ; Lam, Alfred K.
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/: 10.14670/HH-18-329
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info:eu-repo/semantics/article
Description
Abstract
. Vascular endothelial growth factor (VEGF) is
important in pathogenesis of different cancers. The aim
of this study is to investigate the relationships between
different VEGFs and clinicopathological factors in
patients with phaeochromocytomas. Twenty patients (10
men; 10 women) with non-hereditary, non-metastatic
phaeochromocytomas were examined for VEGF mRNA
expressions by polymerase chain reaction. The
expressions were correlated with the clinical and
pathological factors of the patients. In addition, mouse
double minute 2 (MDM2) expression in these tumours
were studied by immunohistochemistry. High
expressions of VEGF-A, VEGF-B, and VEGF-C mRNA
were detected in 11 (55%), 9 (45%), and 9 (45%) of the
tumours respectively. High expression of VEGF-A in
phaeochromocytomas was significantly correlated with
the tumour size (p=0.025) but did not correlate with
patients' age, gender, and tumour laterality. Besides,
there was a trend of VEGF-A expression correlated with
MDM2 expression (p=0.064). On the other hand,
expressions of VEGF-B and VEGF-C were not
significantly correlated with tumour size, patients' age,
gender, tumour laterality, and MDM2 expression. In
addition, high expressions of VEGF-B and VEGF-A
were associated with increase of tumour size (p=0.042).
Co-expression of different VEGFs did not correlate with
MDM2 expression. To conclude, there is a role for
VEGF-A/VEGF-B/VEGF-C in the pathogenesis of nonhereditary, non-metastatic phaeochromocytomas.
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