Publication: Blind aspiration biopsy versus a guided hysteroscopic technique for investigation of the endometrium in infertile women
Authors
Ejzenberg, Dani ; de Jesus Simões, Manuel ; Pinheiro, Walter ; Soares Júnior, José Maria ; Serafini, Paulo Cesar ; Chada Baracat, Edmund
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-725
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info:eu-repo/semantics/article
Description
Abstract
Embryo implantation failure and recurrent
abortion are common indications for endometrial
evaluation to determine the implantation window and
diagnose endometrial anomalies. There are few research
studies comparing the efficacy of different techniques
used for endometrial sampling in infertile females during
the luteal phase. Likewise, morphometric studies of the
endometrium through aspiration biopsy are scant. A
cross-sectional study of 30 infertile and 10 fertile
females was carried out. The study participants
underwent hysteroscopic and aspiration biopsies
(pipelle) at the midluteal phase. Computer-assisted
morphometric and pathological anatomy analyses were
conducted independently by two pathologists blinded to
the study. The two endometrial sampling biopsy
techniques were compared through morphometric and
pathological anatomy analyses using three parameters: a)
the amount of material collected for the endometrial
studies; b) the scope and origin of sampled materials;
and c) the quality of the sample.
Both biopsy techniques produced sufficient material
for analysis. The directed biopsies yielded higher quality
samples from targeted segments of the uterine cavity
because samples were homogeneous and had no
architectural distortion (p<0.05). Blood was present only
in the samples obtained through a Pipelle. Endometritis
was detected in 10% of the infertile women. Our
findings suggest that hysteroscopic biopsies are superior
to blinded aspiration biopsies
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Citation
Histology and Histopathology, Vol.31, nº9, (2016)
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