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Mechanical Intestinal Obstruction in a Porcine Model: Effects of Intra-Abdominal Hypertension. A Preliminary Study

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dc.contributor.authorCorrea-Martín, L.
dc.contributor.authorPárraga Ros, Ester
dc.contributor.authorSánchez-Margallo, Fco
dc.contributor.authorLatorre Reviriego, Rafael Manuel
dc.contributor.authorLópez Albors, Octavio Miguel
dc.contributor.authorWise, R.
dc.contributor.authorMalbrain, M. L. N. G.
dc.contributor.authorCastellanos, G.
dc.contributor.departmentAnatomía y Anatomía Patológica Comparada
dc.date.accessioned2025-12-23T12:22:45Z
dc.date.available2025-12-23T12:22:45Z
dc.date.copyright© 2016 The authors
dc.date.issued2016-02-05
dc.description.abstractIntroduction Mechanical intestinal obstruction is a disorder associated with intra-abdominal hypertensionand abdominal compartment syndrome. As the large intestine intraluminal and intra-abdominal pressures are increased, so the patient’s risk for intestinal ischaemia. Previous studies have focused on hypoperfusion and bacterial translocation without considering the concomitant effect of intra-abdominal hypertension. The objective of this study was to design and evaluate a mechanical intestinal obstruction model in pigs similar to the human pathophysiology. Materials and Methods Fifteen pigs were divided into three groups: a control group (n = 5) and two groups of 5 pigs with intra-abdominal hypertension induced by mechanical intestinal obstruction. The intraabdominal pressures of 20 mmHg were maintained for 2 and 5 hours respectively. Hemodynamic, respiratory and gastric intramucosal pH values, as well as blood tests were recorded every 30 min. Results Significant differences between the control and mechanical intestinal obstruction groups were noted. The mean arterial pressure, cardiac index, dynamic pulmonary compliance and abdominal perfusion pressure decreased. The systemic vascular resistance index, central venous pressure, pulse pressure variation, airway resistance and lactate increased within 2 hours from starting intra-abdominal hypertension (p<0.05). In addition, we observedincreased values for the peak and plateau airway pressures, and low values of gastric intramucosal pH in the mechanical intestinal obstruction groups that were significant after 3 hours. Conclusion The mechanical intestinal obstruction model appears to adequately simulate the pathophysiology of intestinal obstruction that occurs in humans. Monitoring abdominal perfusion pressure, dynamic pulmonary compliance, gastric intramucosal pH and lactate values may provide insight in predicting the effects on endorgan function in patients with mechanical intestinal obstruction.
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dc.format.extent15
dc.identifier.citationPLoS ONE 11(2): e0148058.
dc.identifier.doi10.1371/journal.pone.0148058
dc.identifier.eissn1932-6203
dc.identifier.urihttp://hdl.handle.net/10201/182329
dc.languageeng
dc.publisherPublic Library of Science
dc.relationThis work was supported by one grant from Extremadura Regional Government through the Plan Regional de Investigación de Extremadura (PRI09A161 to Minimally Invasive Surgery Center Jesús Usón).
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleMechanical Intestinal Obstruction in a Porcine Model: Effects of Intra-Abdominal Hypertension. A Preliminary Study
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublication269b9699-1b31-4bb4-82ab-517084bcf737
relation.isAuthorOfPublicationd0c90149-4c92-4e44-b637-88131f331585
relation.isAuthorOfPublication39ee7277-9165-4e46-adc9-72006a802990
relation.isAuthorOfPublication.latestForDiscovery269b9699-1b31-4bb4-82ab-517084bcf737
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