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Alterations of the cerebrospinal fluid proteins and subcommissural organ secretion in the arterial hypertension and ventricular dilatation. A study in SHR rats

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dc.contributor.authorMartínez de la Peña y Valenzuela, Isabeles
dc.contributor.authorCarmona-Calero, E.es
dc.contributor.authorPérez-González, H.
dc.contributor.authorOrmazabal-Ramos, C.
dc.contributor.authorFernández-Rodríguez, P.
dc.contributor.authorGonzalez-Marrero, I.
dc.contributor.authorCastañeyra Perdomo, A.
dc.contributor.authorFerres Torres, R.
dc.date.accessioned2011-06-30T12:02:14Z
dc.date.available2011-06-30T12:02:14Z
dc.date.issued2006
dc.description.abstractThe aim of this work was to analyze the proteins in the cerebrospinal fluid (CSF) of spontaneously hypertensive rats, to study their possible role in the relationship between hydrocephalus, arterial hypertension and alterations in the subcommissural organ. Brains from control Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) sacrificed with chloral hydrate were used. Antiserums against some cerebrospinal fluid protein bands and Reissner’s fiber (RF) were used for immunohistochemical study of the SCO. Ventricular dilation was observed in the lateral and third ventricle of the SHR. Third ventricle ependyma showed immunoreactive material (IRM) for antibody against 141kDa protein band anti-B1 and 117 protein band anti-B2 and the SCO of the SHR showed a decrease of the IRM when compared with WKY rats. An alteration in the expression of anti-RF was found to compare the SCO of the WKY and SHR groups. Our results demonstrate that hydrocephalus and hypertension are interconnected in this kind of rat which produce alterations in SCO secretions and some proteins of the CSF.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22618
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectProteinses
dc.subjectCerebrospinal fluides
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleAlterations of the cerebrospinal fluid proteins and subcommissural organ secretion in the arterial hypertension and ventricular dilatation. A study in SHR ratses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.21, nº 2 (2006)