Publication: Alterations of the cerebrospinal
fluid proteins and subcommissural organ secretion in
the arterial hypertension and ventricular dilatation. A
study in SHR rats
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Date
2006
Authors
Martínez de la Peña y Valenzuela, Isabel ; Carmona-Calero, E. ; Pérez-González, H. ; Ormazabal-Ramos, C. ; Fernández-Rodríguez, P. ; Gonzalez-Marrero, I. ; Castañeyra Perdomo, A. ; Ferres Torres, R.
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Publisher
Murcia : F. Hernández
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Description
Abstract
The aim of this work was to analyze the
proteins in the cerebrospinal fluid (CSF) of
spontaneously hypertensive rats, to study their possible
role in the relationship between hydrocephalus, arterial
hypertension and alterations in the subcommissural
organ. Brains from control Wistar-Kyoto rats (WKY)
and spontaneously hypertensive rats (SHR) sacrificed
with chloral hydrate were used. Antiserums against some
cerebrospinal fluid protein bands and Reissner’s fiber
(RF) were used for immunohistochemical study of the
SCO. Ventricular dilation was observed in the lateral and
third ventricle of the SHR. Third ventricle ependyma
showed immunoreactive material (IRM) for antibody
against 141kDa protein band anti-B1 and 117 protein
band anti-B2 and the SCO of the SHR showed a
decrease of the IRM when compared with WKY rats. An
alteration in the expression of anti-RF was found to
compare the SCO of the WKY and SHR groups. Our
results demonstrate that hydrocephalus and hypertension
are interconnected in this kind of rat which produce
alterations in SCO secretions and some proteins of the
CSF.
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