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Myocardial Connexin-43 and N-Cadherin decrease during vanadium inhalation

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dc.contributor.authorFortoul, Teresa I.
dc.contributor.authorSoto-Mota, Adrian
dc.contributor.authorRojas-Lemus, Marcela
dc.contributor.authorRodriguez-Lara, Vilaney
dc.contributor.authorGonzalezVillalva, Adriana
dc.contributor.authorMontaño, Luis F.
dc.contributor.authorPaez, Araceli
dc.contributor.authorColin-Barenque, Laura
dc.contributor.authorLópez-Valdez, Nelly
dc.contributor.authorCano Gutiérrez, Gumaro
dc.contributor.authorBizarro-Nevares, Patricia
dc.contributor.authorUstarroz-Cano, Martha
dc.date.accessioned2021-06-18T08:39:03Z
dc.date.available2021-06-18T08:39:03Z
dc.date.issued2016
dc.description.abstractParticulate matter air pollution has considerably increased during the last decades; vanadium is a transition element adhered to this particulate matter, and the combustion of fossil fuels is the main source in the atmosphere. It has been reported that air pollution and specifically vanadium exposure increases the probability of suffering arrhythmias; however the biological mechanism of such a relationship remains unknown. It has been established that a diminished presence of NCadherin alters the Connexin-43 arrangement, and the consequent altered presence of these proteins predisposes to ventricular heart rate problems. We analyzed myocardial histology and the expression of N-Cadherin and Connexin-43 by immunohistochemistry in mouse that inhaled vanadium. Our results showed a significant and progressive reduction in both N-Cadherin and Connexin-43, as well as the presence of meganucleus; myofibrils disruption, and clumping in the exposed groups were also observed. Our findings add more information about a possible explanation for the arrythmogenic effect observed in dwellers of cities with high particulate matter atmospheric pollution.es
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dc.format.extent7es
dc.identifier.citationHistology and histopathology: Vol.31, nº4 (2016)
dc.identifier.doiDOI: 10.14670/HH-11-688
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/109904
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAir pollutiones
dc.subjectArrhythmiases
dc.subjectConnexin-43es
dc.subjectN-cadherines
dc.subjectVanadium inhalationes
dc.subjectClumpinges
dc.subjectMyofibrilses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMyocardial Connexin-43 and N-Cadherin decrease during vanadium inhalationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nº4 (2016)