Publication: Myocardial Connexin-43 and N-Cadherin decrease during vanadium inhalation
Authors
Fortoul, Teresa I. ; Soto-Mota, Adrian ; Rojas-Lemus, Marcela ; Rodriguez-Lara, Vilaney ; GonzalezVillalva, Adriana ; Montaño, Luis F. ; Paez, Araceli ; Colin-Barenque, Laura ; López-Valdez, Nelly ; Cano Gutiérrez, Gumaro ; Bizarro-Nevares, Patricia ; Ustarroz-Cano, Martha
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-688
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info:eu-repo/semantics/article
Description
Abstract
Particulate matter air pollution has
considerably increased during the last decades;
vanadium is a transition element adhered to this
particulate matter, and the combustion of fossil fuels is
the main source in the atmosphere.
It has been reported that air pollution and
specifically vanadium exposure increases the probability
of suffering arrhythmias; however the biological
mechanism of such a relationship remains unknown. It
has been established that a diminished presence of NCadherin alters the Connexin-43 arrangement, and the
consequent altered presence of these proteins
predisposes to ventricular heart rate problems.
We analyzed myocardial histology and the
expression of N-Cadherin and Connexin-43 by
immunohistochemistry in mouse that inhaled vanadium.
Our results showed a significant and progressive
reduction in both N-Cadherin and Connexin-43, as well
as the presence of meganucleus; myofibrils disruption,
and clumping in the exposed groups were also observed.
Our findings add more information about a possible
explanation for the arrythmogenic effect observed in
dwellers of cities with high particulate matter
atmospheric pollution.
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Citation
Histology and histopathology: Vol.31, nº4 (2016)
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