Publication: Heritability of sleep quality in a middle-aged twin sample from Spain
Authors
Martínez Selva, José M. ; Sánchez Romera, Juan F. ; Gregory, Alice M. ; Ordoñana, Juan R. ; Madrid Valero, Juan José
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Publisher
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DOI
https://doi.org/10.1093/sleep/zsy110
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info:eu-repo/semantics/article
Description
©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Accepted version of a Published Work that appeared in final form in Sleep. To access the final edited and published work see https://doi.org/10.1093/sleep/zsy110
Abstract
Study objectives: Sleep quality is associated with health throughout the life span,
which is particularly salient in middle-age and older adulthood. Sleep quality appears to
be influenced by both genetic and environmental factors. However, there is still limited
information about genetic influences on sleep quality in middle-aged adults, and
particularly in those from certain geographical locations. We estimated the magnitude of
genetic and environmental influences on sleep quality in a representative sample of
middle-aged Spanish twins.
Methods: The sample comprised 2150 individuals born between 1939 and 1966, who
participate in the Murcia Twin Registry. In order to estimate the heritability of sleep
quality variables we performed univariate analyses for the global score on the
Pittsburgh sleep quality index and for each of its components.
Results: We found moderate but significant heritability (34%) for sleep quality. The
genetic variance of the components of the Pittsburgh index ranged from 30% to 45%,
except for sleep efficiency for which no genetic influence could be detected. In
summary, there was a moderate genetic influence on most dimensions of sleep quality
in a sample of adult male and female twins. Shared environment influences were not
found.
Conclusions: This study adds new information regarding the underlying determinants
of sleep quality by providing heritability estimates in a middle-aged population-based
representative sample from a geographical location that has not been included in studies
of this type previously. This could provide a reference point for future research
regarding sleep research in middle-age.
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