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PublicationOpen AccessReport of "Host Defense Peptide Hepcidin 1 and Iron Overload Differentially Modulate Energy, Lipid, and Hepatic–Biliary Metabolic Pathways in Gilthead Seabream (Sparus aurata) Blood"(2025) Laura García-Navarro; Serna Duque, John Alberto; Marín Parra, Claudia; Esteban Abad, María de los Ángeles; Esteban Abad, María de los Ángeles; Biología Celular e Histología; Esteban Abad, María de los Ángeles; Facultades de la UMU::Facultad de BiologíaHepcidin 1 (HDP, antimicrobial and iron regulator peptide) and iron overload are relevant in aquaculture, but their in vivo physiological effects in healthy fish are poorly characterized. This study evaluated how intraperitoneal injections of hepcidin 1, iron (iron-dextran), and a sequential treatment (iron and hepcidin 1) modulate the blood metabolome of gilthead sea bream (Sparus aurata) at 10 days, due to their adaptive role in response to systemic changes. Multivariate analyses showed metabolomic alterations in all three situations, although weak at 10 days; in the iron→hepcidin 1 group, the separation in PCA was not significant (P=0.247), suggesting overlap or absence of unidirectional shift. In all three treatments, 15 chemical superclasses were conserved (predominance of lipids), indicating quantitative reorganization. There was an activation of energy metabolism coupled with immune response, involving lipids, fatty acids, acyl-CoA/acylcarnitines, and signals from one-carbon metabolism (folate/serine/methionine) connected to NAD(H)/NADP(H) and redox balance, although several associations lost robustness (non-significant FDR), consistent with a return to homeostasis. Hepcidin 1 was associated with increased adenosine, Lys-Glu-Leu tripeptide, dodecanoylcarnitine and phosphoethanolamines/phosphocholines (LysoPE/PE/LysoPC), along with a decrease in exogenous compounds (e.g., erythromycin C, harzianopyridone), suggesting modulation of the gut–microbiota–barrier axis or hepatic-biliary clearance. Iron overload induced reprogramming compatible with reactive oxygen species management (increase in catalposide and L-NIL/L-NILL-type metabolites), lipid remodeling (decrease in PC/PE/PS, cholesterol esters and triglycerides), and greater mitochondrial mobilization of fatty acids (increase in linoleylcarnitine), without clear markers of peroxidation, liver damage or inflammation; herbicides (bensulfuron/sulfometuron methyl) were also reduced. In the iron and hepcidin 1 group, metabolites pointed to three axes: β-oxidation/fatty acid transport, phospho-/sphingolipid remodeling, and hepatic-biliary involvement with possible microbiota alteration. In conclusion, hepcidin 1 and iron modulate energy and lipid metabolism in gilthead sea bream blood, providing biomarkers and a framework for interpreting immunometabolic adaptations in aquaculture, although targeted validation of annotations and higher temporal resolution are required.- PublicationRestrictedDatos cualitativos: Transcripciones de entrevistas a expertos y grupos focales del estudios "La Tercera Ciencia"(2026-06-30) González García, Rocío; Roca Marín, Delfina; Roca Marín, Delfina; Comunicación; Roca Marín Delfina; Unidad de Cultura Científica y de la InnovaciónEsta publicación recopila los datos cualitativos y las transcripciones completas obtenidas a partir de los grupos focales desarrollados en el marco de La Tercera Ciencia, un proyecto financiado por la Fundación Española para la Ciencia y la Tecnología (FECYT) del Ministerio de Ciencia, Innovación y Universidades. El documento reúne la información recogida de 140 participantes mayores de 65 años, organizados en distintos grupos focales. Estos fueron configurados atendiendo a criterios de género, nivel educativo y otras variables sociodemográficas, con el fin de garantizar la diversidad y representatividad de la muestra. Este material ofrece un registro detallado de las percepciones, experiencias y reflexiones de los participantes en torno a la comunicación científica.
- PublicationOpen AccessDataset used for the study titled: When films move faces: Tracking viewers’ emotional engagement when watching a dubbed vs. subtitled movie(2026-06-30) Sánchez Mompeán, Sofía; Rojo López, Ana María; Soto, Concepción; Traducción e Interpretación
- PublicationOpen AccessReduced hepcidin 1 of gilthead seabream (Sparus aurata): Immunomodulatory effects and implications in iron homeostasis(2026) Marín Parra, Claudia; García, Laura; Serna Duque, John Alberto; Ortiz García, María; Martínez López, Salvadora; R. Coxon, Christopher; Espinosa Ruiz, Cristóbal; Esteban Abad, María de los Ángeles; Esteban Abad, María de los Ángeles; Biología Celular e Histología; María Ángeles Esteban Abad; Facultades de la UMU::Facultad de Biología
- PublicationOpen AccessDataset used for the study entitled: A Longitudinal Robust Linear Mixed-Effects Analysis.(2026-06-15) Villarejo García, Diego; Actividad Física y Deporte; Facultades de la UMU::Facultad de Ciencias del DeporteMETHODOLOGICAL INFORMATION AND SAMPLE SIZE This study followed a longitudinal, prospective, and multi-cohort quasi-experimental design. The initial clinical recruitment comprised 72 breast cancer survivors referred by the Murcian Health Service (Servicio Murciano de Salud, SMS) across health zones 1, 6, and 7. The source population presented high clinical heterogeneity, incorporating patients undergoing both conservative surgical procedures (lumpectomy, quadrantectomy, oncoplasty; 37.5%, n = 16) and radical/non-conservative interventions (complete, modified, or bilateral mastectomy; 52.8%, $n = 23$; along with additional bilateral procedures, 9.7%, $n = 4$), combined with or without axillary lymph node dissection and sentinel lymph node biopsy. The final statistical monitoring focused on a strict per-protocol sample of 36 participants ($n = 36$) who complied with the clinical compliance threshold (Cumulative Attendance Percentage > 33.33%) and possessed complete data rows across all operational time points. Neuromuscular performance was tracked at baseline pre-intervention (PRE) and following a 12-week supervised resistance training macrocycle (POST). Because each participant was measured repeatedly across both upper limbs (Operated vs. Non-Operated), the final longitudinal data matrix contains a total volume of exactly $N = 128$ independent longitudinal observations ($obs$) clustered hierarchically within patients.