Publication: Advances in translational orthopaedic research with species-specific multipotent mesenchymal stromal cells derived from the umbilical cord
Authors
Ramallo, Melina ; Carreras Sánchez, Irene ; López Fernández, Alba ; Vélez, Roberto ; Aguirre, Màrius ; Feldman, Sara ; Vives, Joaquim
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-18-249
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info:eu-repo/semantics/article
Description
Abstract
Compliance with current regulations for the
development of innovative medicines require the testing
of candidate therapies in relevant translational animal
models prior to human use. This poses a great challenge
when the drug is composed of cells, not only because of
the living nature of the active ingredient but also due to
its human origin, which can subsequently lead to a
xenogeneic response in the animals. Although
immunosuppression is a plausible solution, this is not
suitable for large animals and may also influence the
results of the study by altering mechanisms of action that
are, in fact, poorly understood. For this reason, a number
of procedures have been developed to isolate
homologous species-specific cell types to address
preclinical pharmacodynamics, pharmacokinetics and
toxicology. In this work, we present and discuss
advances in the methodologies for derivation of
multipotent Mesenchymal Stromal Cells derived from
the umbilical cord, in general, and Wharton’s jelly, in
particular, from medium to large animals of interest in
orthopaedics research, as well as current and potential
applications in studies addressing proof of concept and
preclinical regulatory aspects.
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Citation
Histology and Histopathology, Vol.36, nº1, (2021)
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