Publication:
Monitoring of soluble forms of BAFF System (BAFF, APRIL, sR-BAFF, sTACI and sBCMA) in kidney transplantation

Simple item page
dc.contributor.authorAlfaro, Rafael
dc.contributor.authorLlorente, Santiago
dc.contributor.authorMartínez, Pedro
dc.contributor.authorJiménez Coll, Víctor
dc.contributor.authorMartínez Banaclocha, Helios
dc.contributor.authorGalián, José Antonio
dc.contributor.authorBotella, Carmen
dc.contributor.authorMoya Quiles, María Rosa
dc.contributor.authorPeña Moral, Jesús de la
dc.contributor.authorMinguela, Alfredo
dc.contributor.authorMuro, Manuel
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-08T11:37:14Z
dc.date.available2024-07-08T11:37:14Z
dc.date.issued2022-09-22
dc.description© L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Archivum Immunologiae et Therapiae Experimentalis. To access the final edited and published work see https://doi.org/10.1007/s00005-022-00659-4
dc.description.abstractBAFF system plays an essential role in B cells homeostasis and tolerance, although it has widely not been tested in transplantation with doubtful results. The main purpose was to study the BAFF soluble forms and their correlation with acute rejection (AR) and donor-specific antibodies production. Serum levels of BAFF, APRIL, and soluble forms of their receptors were analyzed in renal recipients with and without acute rejection (AR/NAR) appearance. All molecules were evaluated at pre- and post-transplantation. sTACI showed a significant correlation with BAFF and sR-BAFF levels, and sBCMA also showed a positive correlation with sAPRIL levels. A significant increase in sAPRIL levels in patients suffering AR was also found, and ROC curves analysis showed an AUC = 0.724, a concentration of 6.05 ng/ml (sensitivity: 66.7%; specificity: 73.3%), the best cutoff point for predicting AR. In the post-transplant dynamics of sAPRIL levels in the longitudinal cohort, we observed a significant decrease at 3 and 6 month post-transplantation compared to pretransplantation status. We also observed that recipients with high pre-transplant levels of sAPRIL generated antibodies earlier than those with lower sAPRIL levels, although their long-term post-transplantation was not different. Our results show that elevated serum levels of APRIL may be helpful as a biomarker for the diagnosis of AR, although the longitudinal study shows that it is not helpful as a prognostic biomarker.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationArchivum Immunologiae et Therapiae Experimentalis (2022) 70:21
dc.identifier.doihttps://doi.org/10.1007/s00005-022-00659-4
dc.identifier.issnPrint: 0004-069X
dc.identifier.issnElectronic: 1661-4917
dc.identifier.urihttp://hdl.handle.net/10201/142911
dc.languageenges
dc.publisherSpringer
dc.relationOur work was possible thanks to support from Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness. Grant Number PI15/01370, P19/01194, and PI20/00050 and co-funding the European Union with the European Fund of Regional Development (FEDER) with the principle of “A manner to build Europe”es
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s00005-022-00659-4
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBAFF system soluble formses
dc.subjectAcute rejectiones
dc.subjectKidney transplantes
dc.subjectForensic medicinees
dc.titleMonitoring of soluble forms of BAFF System (BAFF, APRIL, sR-BAFF, sTACI and sBCMA) in kidney transplantationes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s00005-022-00659-4.pdf
Size:
913.34 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos