Publication: Peptidergic (VIP) nerves in normal human pancreas and in pancreatitis, an immunohistochemical study
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Date
1993
Authors
Marongiu, L. ; Perra, M. T. ; Pinna, A.D. ; Sirigu, F. ; Sirigu, P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Vasoactive intestinal polypeptide was
demonstrated in the nerves of the human normal
pancreas and in pancreatitis by light microscope
immunohistochemical technique. In specimens of
normal pancreas, vasoactive intestinal polypeptideimmunoreactive
neuronal cells were present in the
autonomic ganglia. These ganglia were found to receive
an abundant supply of vasoactive intestinal polypeptidepositive
fibre plexuses. Immunoreactive nerve fibres
were seen to run in the stroma, in association with
secretory acini, ducts and blood vessels. Vasoactive
intestinal polypeptide-positive fibres were also seen
close to the Langerhans' islets, but no vasoactive
intestinal polypeptide-like immunoreactivity was
observed in the endocrine cells. In specimens from
patients affected by pancreatitis, even in lesioned
regions, immunoreactive elements were extremely
scarce.
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