Publication: Evaluation of the corneal endothelium in patients with diabetes mellitus type I and II
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Date
2010
Authors
Módis Jr, László ; Szalai, Eszter ; Kertész, Katalin ; Kemény-Beke, Ádám ; Kettesy, Beáta ; Berta, Andras
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Background: The aim of the present study is
to determine corneal physiology and endothelial
morphology after proper image analysis technique in
type I and II diabetic patients. The HbA1c level and the
grade of retinopathy were also recorded and correlated
with the endothelial parameters. Methods: 41 eyes of 21
patients with type I and 59 eyes of 30 patients with type
II diabetes mellitus (mean age was 40.97±15.46 and
64.36±10.47 years) were examined and compared to
age-matched controls. Endothelial cell density (ECD),
mean cell area, coefficient of variation of cell area,
central corneal thickness, intraocular pressure, and grade
of retinopathy were recorded. Results: There was a
statistically significant decreased endothelial cell density
in type I disease (2428±219 cell/mm2) in comparison
with healthy subjects (2495±191 cell/mm2, P=0.02). The
diabetic corneas were thicker than normal (P=0.001).
The HbA1c level was inversely correlated with the ECD
(r=-0.60; P<0.0001) and correlated with the mean
endothelial cell area (r=0.60, P<0.0001). Significant
correlation was observed between the endothelial
morphology and grade of diabetic retinopathy (r=-0.40,
ECD; r=0.38, mean cell area; P=0.01 for both). In type II
diabetes mellitus no significant difference was found in
the evaluated values. Conclusions: The present study
disclosed the alteration of the corneal endothelial
morphology in type I diabetes mellitus as compared to
normal subjects. The results indicated that type I diabetic
corneas are more susceptible to environmental changes
than type II corneas.
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