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Evaluation of the corneal endothelium in patients with diabetes mellitus type I and II

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dc.contributor.authorMódis Jr, Lászlóes
dc.contributor.authorSzalai, Eszteres
dc.contributor.authorKertész, Katalin
dc.contributor.authorKemény-Beke, Ádám
dc.contributor.authorKettesy, Beáta
dc.contributor.authorBerta, Andras
dc.date.accessioned2015-09-29T07:19:06Z
dc.date.available2015-09-29T07:19:06Z
dc.date.issued2010
dc.description.abstractBackground: The aim of the present study is to determine corneal physiology and endothelial morphology after proper image analysis technique in type I and II diabetic patients. The HbA1c level and the grade of retinopathy were also recorded and correlated with the endothelial parameters. Methods: 41 eyes of 21 patients with type I and 59 eyes of 30 patients with type II diabetes mellitus (mean age was 40.97±15.46 and 64.36±10.47 years) were examined and compared to age-matched controls. Endothelial cell density (ECD), mean cell area, coefficient of variation of cell area, central corneal thickness, intraocular pressure, and grade of retinopathy were recorded. Results: There was a statistically significant decreased endothelial cell density in type I disease (2428±219 cell/mm2) in comparison with healthy subjects (2495±191 cell/mm2, P=0.02). The diabetic corneas were thicker than normal (P=0.001). The HbA1c level was inversely correlated with the ECD (r=-0.60; P<0.0001) and correlated with the mean endothelial cell area (r=0.60, P<0.0001). Significant correlation was observed between the endothelial morphology and grade of diabetic retinopathy (r=-0.40, ECD; r=0.38, mean cell area; P=0.01 for both). In type II diabetes mellitus no significant difference was found in the evaluated values. Conclusions: The present study disclosed the alteration of the corneal endothelial morphology in type I diabetes mellitus as compared to normal subjects. The results indicated that type I diabetic corneas are more susceptible to environmental changes than type II corneas.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/46374
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDiabetes mellituses
dc.subjectCorneal endothelial morphologyes
dc.subject.other61 - Medicinaes
dc.titleEvaluation of the corneal endothelium in patients with diabetes mellitus type I and IIes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25,nº12 (2010)