Publication: Cytototoxic effects of paracetamol (acetaminophen) in Allium cepa L. meristematic cells and seed germination
Authors
Ortiz Molina, Gisele ; Gouvea Buchweitz, Jéssica ; Aguiar, Rosiane Borba de
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Publisher
Universidad de Murcia. Servicio de publicaciones
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Description
Abstract
El desecho de medicamentos en la basura doméstica puede ser
muy peligrosa para el medio ambiente. El presente trabajo buscó
evaluar parámetros de toxicidad del contaminante emergente paracetamol. En los ensayos se utilizaron tres dosis de paracetamol
(0,4 mg L-1, 0,5 mg L-1 y 0,6 mg L-1). Los resultados mostraron que
la exposición aguda al paracetamol induce varios daños clastogénicos y aneugénicos en el test de A. cepa. No se encontró ningún
efecto en la germinación. Aunque el paracetamol es un fármaco
importante, también puede representar un riesgo significativo para
la producción agrícola y la preservación del medio ambiente. Los
resultados del presente trabajo corroboran datos anteriores y refuerzan que la exposición a contaminantes farmacéuticos puede
representar un problema significativo para la producción de alimentos, el equilibrio ambiental y la preservación de especies.
Disposing medicines in the common domestic waste can be very harmful to the environment. The present work aimed to evaluate toxicity parameters of exposure to micropollutant acetaminophen. Three paracetamol doses (0.4 mg L -1, 0.5 mg L -1 and 0.6 mg L -1) were used in the tests. Results showed that acute exposure to paracetamol causes several chromosomal aberrations of both clastogenic and aneugenic nature in the A. cepa test, which are indicative of paracetamol genotoxic action. No effect in germination was found. Although paracetamol is an important pharmaceutical that contributes to human wellbeing, it may also represent a significant risk to agricultural production and environmental preservation. The results in the present work corroborate data from previous publications and reinforce that exposure to pharmaceutical micropollutants may represent a significant problem to food production, environmental balance and species preservation.
Disposing medicines in the common domestic waste can be very harmful to the environment. The present work aimed to evaluate toxicity parameters of exposure to micropollutant acetaminophen. Three paracetamol doses (0.4 mg L -1, 0.5 mg L -1 and 0.6 mg L -1) were used in the tests. Results showed that acute exposure to paracetamol causes several chromosomal aberrations of both clastogenic and aneugenic nature in the A. cepa test, which are indicative of paracetamol genotoxic action. No effect in germination was found. Although paracetamol is an important pharmaceutical that contributes to human wellbeing, it may also represent a significant risk to agricultural production and environmental preservation. The results in the present work corroborate data from previous publications and reinforce that exposure to pharmaceutical micropollutants may represent a significant problem to food production, environmental balance and species preservation.
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