Publication: Brain injections of glial cytoplasmicinclusions induce a multiple systematrophy-like pathology
Loading...
Date
2022-03-14
Authors
Margaux, Teil ; Dovero, Sandra ; Bourdenx, Mathieu ; Arotcarena, Marie-Laure ; Camus, Sandrine ; Porras, Gregory ; Thiolat, Marie-Laure ; Trigo-Damas, Ines ; Perier, Celine ; Estrada, Cristina ; Garcia-Carrillo, Nuria ; Morari, Michele ; Meissner, Wassilios G. ; Vila, Miquel ; Obeso, Jose A. ; Bezard, Erwan ; Dehay, Benjamin ; Herrero Ezquerro, María Trinidad
item.page.secondaryauthor
item.page.director
Publisher
Oxford University Pres
publication.page.editor
publication.page.department
DOI
https://doi.org/10.1093/brain/awab374
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Synucleinopathies encompass several neurodegenerative diseases, which include Parkinson’s disease, dementiawith Lewy bodies and multiple system atrophy. These diseases are characterized by the deposit ofa-synucleinaggregates in intracellular inclusions in neurons and glial cells. Unlike Parkinson’s disease and dementia withLewy bodies, where aggregates are predominantly neuronal, multiple system atrophy is associated witha-synu-clein cytoplasmic inclusions in oligodendrocytes. Glial cytoplasmic inclusions are the pathological hallmark ofmultiple system atrophy and are associated with neuroinflammation, modest demyelination and, ultimately, neu-rodegeneration.To evaluate the possible pathogenic role of glial cytoplasmic inclusions, we inoculated glial cytoplasmic inclusion-containing brain fractions obtained from multiple system atrophy patients into the striatum of non-human pri-mates. After a 2-yearin vivophase, extensive histochemical and biochemical analyses were performed on thewhole brain.We found loss of both nigral dopamine neurons and striatal medium spiny neurons, as well as loss of oligodendro-cytes in the same regions, which are characteristics of multiple system atrophy. Furthermore, demyelination, neu-roinflammation anda-synuclein pathology were also observed. These results show that thea-synuclein species inmultiple system atrophy-derived glial cytoplasmic inclusions can induce a pathological process in non-human pri-mates, including nigrostriatal and striatofugal neurodegeneration, oligodendroglial cell loss, synucleinopathy andgliosis.The present data pave the way for using this experimental model for MSA research and therapeutic development
publication.page.subject
Citation
Brain n 145, año 2022
item.page.embargo
1-ene-2999
Collections
Ir a Estadísticas
Sin licencia Creative Commons.