Publication: Proliferation and distribution of adrenocortical cells in the gland of ACTH- or dexamethasone-treated rats
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Date
1990
Authors
Stachowiak, A. ; Nussdorfer, G.G. ; Malendowicz, L.K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of prolonged (7-day) ACTH and
dexamethasone administrations on rat adrenocorticalcell
turnover have been investigated by combined
stereological and metaphase-arrest techniques. ACTH
was found to increase the number of parenchymal cells in
each adrenal zone; however, ACTH altered the cell
distribution in the cortex, lowering their percentage in
the zona glomerulosa (ZG) and zona fasciculata (ZF)
and enhancing it in the zona reticularis (ZR). The cell
birth-rate was markedly raised by ACTH exclusively in
ZG and ZF. Dexamethasone notably decreased the
number of ZF and ZR cells, without altering that of ZG
cells. Moreover. dexamethasone increased the percentage
of parenchymal cells in ZG and ZF, and lowered
it in ZR. In the adrenal cortices of dexamethasoneadministered
animals, metaphases were virtually absent.
These data indicate that ACTH increases the cell birthrate
in ZG and possibly ZF, and enhances the centripetal
migration of newly-formed cells and their accumulation
in ZR. Dexamethasone inhibits both proliferation of
adrenocortical cells in the outer cortical layers and their
centripetal migration into ZR. Moreover, it appears to
cause parenchymal-cell loss in the inner adrenocortical
layers.
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