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Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure

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dc.contributor.authorPeres Rubio, Camila
dc.contributor.authorSaril, A.
dc.contributor.authorKocaturk, M.
dc.contributor.authorTanaka, R.
dc.contributor.authorKoch, J.
dc.contributor.authorCerón, J.J.
dc.contributor.authorYilmaz, Z.
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-02-01T22:10:19Z
dc.date.available2025-02-01T22:10:19Z
dc.date.issued2020-11-10
dc.description© 2020 The Authors This document is the published version of a published work that appeared in final form in BMC Veterinary Research This document is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0 To access the final edited and published work see: https://doi.org/10.1186/s12917-020-02650-7
dc.description.abstractBackground: Heart failure (HF) is associated with changes in inflammatory and oxidative stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarkers in dogs with different stages of HF and its relation with the severity of the disease and echocardiographic changes. A total of 29 dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included and classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage HF) according to the ACVIM staging system. In these dogs an ecnhocardiographic examination was performed and cytokines, and inflammatory and oxidative stress markers were evaluated in serum. Results: KC-like was significantly increased in dogs of stage-C (P<0.01) and -D (P < 0.05) compared with stage-A and -B. Stage-D dogs showed significantly higher serum CRP and Hp (P < 0.05) but lower serum antioxidant capacity (PON1, TEAC, CUPRAC, and thiol) compared to stage-A and -B (P < 0.05). After the treatment, serum levels of CRP, Hp and KClike decreased and serum antioxidant levels increased compared to their pre-treatment values. Left ventricular dimension and LA/Ao ratio correlated positively with CRP, MCP-1, and KC-like but negatively with PON1, GM-CSF, IL-7 and antioxidant biomarkers (P < 0.01). Conclusion: Our results showed that dogs with advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF. Some of these biomarkers of inflammation and oxidative stress could have the potential to be biomarkers to monitor the severity of the disease and the effect of treatment.
dc.formatapplication/pdfes
dc.format.extent14
dc.identifier.doihttps://doi.org/10.1186/s12917-020-02650-7
dc.identifier.eisbnBMC Veterinary Research, 16(1), 2020. ISSN: 1746-6148es
dc.identifier.issn1746-6148
dc.identifier.urihttp://hdl.handle.net/10201/149926
dc.languageenges
dc.publisherBioMed Central (BMC)
dc.relation-Bursa Uludag University Research Fund -Uludag University Research Fundes
dc.relation.publisherversionhttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-020-02650-7#citeas
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCytokines
dc.subjectChemokines
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectHeart failure
dc.subjectDogs
dc.titleChanges of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failurees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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