Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies

Pacheco-González, Rosa M.; Garcia-Marcos, Luis; Morales, Eva

Publication:
Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies

dc.contributor.author	Pacheco-González, Rosa M.
dc.contributor.author	Garcia-Marcos, Luis
dc.contributor.author	Morales, Eva
dc.contributor.department	Ciencias Sociosanitarias
dc.date.accessioned	2024-01-31T08:35:35Z
dc.date.available	2024-01-31T08:35:35Z
dc.date.issued	2018-05
dc.description	Acceso restringido
dc.description.abstract	Background: Prenatal vitamin D status may influence offspring’s respiratory and allergic outcomes; however, evidence is inconclusive. A systematic review and metaanalysis were conducted on the association between 25-hydroxyvitamin D [25(OH) D] levels in maternal blood in pregnancy or cord blood at birth with the risk of offspring’s respiratory and allergic conditions. Methods: Two independent researchers conducted systematic searches for observational studies published until May 2017 using defined keywords on vitamin D and health outcomes, including respiratory tract infections (RTIs), wheeze, asthma, atopic eczema, allergic rhinitis, allergic sensitization, and lung function. Random-effects meta-analyses were conducted. Results: A total of 34 from 547 retrieved articles were included. Increased prenatal exposure to 25(OH)D was inversely associated with risk of RTIs. Comparing the highest with the lowest category of 25(OH)D levels, the pooled odds ratio was 0.64 (95% CI 0.47, 0.87). A positive borderline association was found for lung function at school age (FEV1 z-score coefficient 0.07, 95% CI -0.01, 0.15). No associations were found for wheeze, asthma, atopic eczema, allergic rhinitis, and allergic sensitization. Conclusion: The introduction of public health measures to tackle vitamin D status in pregnancy may reduce the burden of RTIs in offspring. Current evidence does not support an impact on asthma and allergy.	en
dc.embargo.terms	Si
dc.format	application/pdf	es
dc.identifier.citation	Pediatr Allergy Immunol. 2018 May 29(3):243-253
dc.identifier.doi	10.1111/pai.12876
dc.identifier.issn	Print 0905-6157
dc.identifier.issn	Electronic 1399-3038
dc.identifier.uri	http://hdl.handle.net/10201/138243
dc.language	eng	es
dc.relation	Miguel Servet fellowship MS14/00046 awarded by the Spanish Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) and Fondos FEDER.	es
dc.rights	info:eu-repo/semantics/embargoedAccess	es
dc.subject	Allergy	en
dc.subject	Asthma	en
dc.subject	Meta-analysis	en
dc.subject	Pregnancy	en
dc.subject	Vitamin D	en
dc.title	Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es