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Advanced sperm selection strategies as a treatment for infertile couples: a systematic review

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dc.contributor.authorJordi Ribas-Maynou
dc.contributor.authorBarranco Cascales, Isabel
dc.contributor.authorSorolla Segura, María
dc.contributor.authorLlavanera, Marc
dc.contributor.authorDelgado Bermúdez, Ariadna
dc.contributor.authorYeste, Marc
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2025-10-17T10:00:19Z
dc.date.available2025-10-17T10:00:19Z
dc.date.copyright© 2022 by the authors
dc.date.issued2022-11-10
dc.description.abstractAssisted reproductive technology (ART) is an essential tool to overcome infertility, and is a worldwide disease that affects millions of couples at reproductive age. Sperm selection is a crucial step in ART treatment, as it ensures the use of the highest quality sperm for fertilization, thus increasing the chances of a positive outcome. In recent years, advanced sperm selection strategies for ART have been developed with the aim of mimicking the physiological sperm selection that occurs in the female genital tract. This systematic review sought to evaluate whether advanced sperm selection techniques could improve ART outcomes and sperm quality/functionality parameters compared to traditional sperm selection methods (swim-up or density gradients) in infertile couples. According to preferred reporting items for systematic reviews and meta-analyses (PRISMA guidelines), the inclusion and exclusion criteria were defined in a PICOS (population, intervention, comparator, outcome, study) table. A systematic search of the available literature published in MEDLINE-PubMed until December 2021 was subsequently conducted. Although 4237 articles were recorded after an initial search, only 47 studies were finally included. Most reports (30/47; 63.8%) revealed an improvement in ART outcomes after conducting advanced vs. traditional sperm selection methods. Among those that also assessed sperm quality/functionality parameters (12/47), there was a consensus (10/12; 83.3%) about the beneficial effect of advanced sperm selection methods on these variables. In conclusion, the application of advanced sperm selection methods improves ART outcomes. In spite of this, as no differences in the reproductive efficiency between advanced methods has been reported, none can be pointed out as a gold standard to be conducted routinely. Further research addressing whether the efficiency of each method relies on the etiology of infertility is warranted.
dc.formatapplication/pdf
dc.format.extent30
dc.identifier.citationInternational Journal of Molecular Sciences, 2022, Vol. 23, Issue 22 : 13859
dc.identifier.doihttps://doi.org/10.3390/ijms232213859
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10201/167350
dc.languageeng
dc.publisherMDPI
dc.relationThe authors acknowledge the support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie agreement No. 801342 (Grant: TECSPR-19-1-0003), the European Union’s Horizon 2020 research and innovation programme (Grant: H2020-MSCA-IF-2019-891382), the Regional Government of Catalonia, Spain (Grant: 2017-SGR-1229), La Marató de TV3 Foundation (214/857-202039), and the Catalan Institution for Research and Advanced Studies (ICREA).
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/23/22/13859
dc.rightsAttribution 4.0 International
dc.rightshttp://creativecommons.org/licenses/by/4.0/
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.subjectICSI
dc.subjectIVF
dc.subjectFertility
dc.subjectInfertility
dc.subjectSperm quality
dc.subjectSperm selection techniques
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleAdvanced sperm selection strategies as a treatment for infertile couples: a systematic review
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublicationes
relation.isAuthorOfPublication3c34d0d5-7d7d-4bcc-a119-8906f53baa7b
relation.isAuthorOfPublication.latestForDiscovery3c34d0d5-7d7d-4bcc-a119-8906f53baa7b
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