Publication: Effect of octreotide on expression of calcitonin gene in cultured cells of medullary thyroid carcinoma
Authors
Zabel, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The studies were performed on cultured TT
cells, originating from medullary thyroid carcinoma and
producing calcitonin (CT) and CT gene-related peptide
(CGRP), synthesized on the template of the same gene.
Addition of octreotide (a synthetic somatostatin
analogue) to the cell culture augmented amounts of
CGRP mRNA and of CGRP protein in the cells as well
as increased levels of CGRP in the culture medium. In
contrast, amounts of CT mRNA and of CT protein in the
cells as well as levels of CT in the medium remained
unchanged. The results showed that octreotide stimulates
transcription and alternate splicing of the CT gene.
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