Publication:
Association between Pulpal-Periapical Pathology and Autoimmune Diseases: A Systematic Review

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Date
2021
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Authors
Guerrero Gironés, Julia ; Pecci Lloret, María Pilar ; Rodríguez Lozano, Francisco Javier ; Pecci Lloret, Miguel Ramón ; Ros Valverde, Antonio
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Publisher
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Dermatología, Estomatología, Radiología y Medicina Física
DOI
https://doi.org/10.3390/jcm10214886
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info:eu-repo/semantics/article
Description
©<2021>. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by /4.0/ This document is the Published, version of a Published Work that appeared in final form in [Journal of Clinical Medicine]. To access the final edited and published work see[https://doi.org/10.3390/jcm10214886]
Abstract
Several studies have linked apical periodontitis and systemic diseases. The aim of this study is to present a systematic review of the available literature investigating whether there is an association between pulpal-periapical pathology and autoimmune disease. The review was conducted following the PRISMA statement. A literature search was performed in five databases. Studies involving patients with pulpal-periapical pathology and autoimmune diseases were included in the review. Based on the PICO model, the research question aimed to assess whether there is an increased risk of developing pulpal-periapical pathology in patients with autoimmune disease. Article selection, data extraction, and quality assessment were performed using an adapted version of the STROBE guidelines. A total of seven studies were included in our review. The types of articles were five case-control and two cross-sectional studies. Periapical pathologies were associated to three autoimmune diseases (diabetes mellitus I, rheumatoid arthritis, and inflammatory bowel disease). Among the included studies, four show a low risk of bias, while three present a moderate risk. There could be an association between apical periodontitis and autoimmune diseases, although most studies report statistically non-significant associations.
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apical periodontitis , irreversible pulpitis , autoimmune disease , type I diabetes mellitus , rheumatoid arthritis , inflammatory bowel disease
Citation
10
Journal of Clinical Medicine
https://www.mdpi.com/journal/jcm
URI
http://hdl.handle.net/10201/119063
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