Publication: Expression of WIF-1 in inflammatory bowel disease
Authors
Terry, Robert ; Chintanaboina, JayaKrishna ; Patel, Deep ; Lippert, Brittany ; Haner, Matthew ; Price, Kimberly ; Tracy, Amanda ; Lalos, Alexander ; Wakeley, Michelle ; Gutierrez, Linda S.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-18-031
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info:eu-repo/semantics/article
Description
Abstract
The WNT/β-catenin cellular network has
been extensively studied in numerous diseases including
inflammatory bowel disease (IBD). IBD is a condition
that increases the risk of developing colorectal cancer.
WIF-1 is an inhibitory protein that acts by blocking the
interactions of WNT with its receptor complex, thus
leading to downregulation of end products of this
pathway. While WIF-1 has been characterized in several
cancers, its relationship with IBD has yet to be
elucidated. In this study, the expression of WIF-1 in
patients with IBD was analyzed in order to provide
insights into the pathophysiology and rationale for
alternative therapies. Biopsies of both normal and
inflamed colonic mucosa from patients with Crohn’s
disease or ulcerative colitis were histologically examined
for the degree of morphologic changes, immune cell
infiltration and presence of WIF-1 through
immunohistochemistry. No differences were observed in
WIF-1 expression linked to a particular condition, but
WIF-1 stain was significantly enhanced in the crypts and
lamina propria as inflammation increased in biopsies
from patients with both, ulcerative colitis and Crohn’s
disease. These findings could give guidance to new
therapeutic applications of the WNT/β-catenin system
and WIF-1 in IBD.
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