Publication: Alternate costimulatory molecules
in T cell activation: differential mechanisms
for directing the immune response
Authors
Kohlmeier, J.E. ; Benedict, S.H.
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Publisher
Murcia : F. Hernández
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Description
Abstract
T cells are required for an effective immune
response against a wide range of pathogens and for the
generation of immunological memory. T cell activation
can be divided into two phases: an antigen-specific
signal delivered through the T cell antigen receptor, and
a costimulatory signal delivered through accessory
molecules on the T cell surface. Following activation, T
cells differentiate to acquire distinct effector functions
depending on the costimulatory signal, cytokine
environment, and the pathogen itself. Although CD28
has been identified as the dominant costimulatory
molecule, several other molecules have been described
as having a costimulatory function. This review will
focus on recent evidence for the existence of alternate
costimulatory molecules, and the differential roles they
might play in the activation, development, and survival
of T cells.
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