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Targeting NRF2 to suppress ferroptosis in brain injury

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dc.contributor.authorSong, Shunchen
dc.contributor.authorGao, Yaxuan
dc.contributor.authorSheng, Yi
dc.contributor.authorRui, Tongyu
dc.contributor.authorLuo, Chengliang
dc.date.accessioned2023-01-11T10:01:18Z
dc.date.available2023-01-11T10:01:18Z
dc.date.issued2021
dc.description.abstracty. Brain injury is accompanied by serious iron metabolism disorder and oxidative stress. As a novel form of regulated cell death (RCD) depending on lipid peroxidation caused by iron overload, ferroptosis (FPT) further aggravates brain injury, which is different from apoptosis, autophagy and other traditional cell death in terms of biochemistry, morphology and genetics. Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death. Importantly, NRF2 can reduce iron load and resist FPT. In the future, it is expected to open up a new way to treat brain injury by targeting NRF2 to alleviate FPT in brain.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationHistology and Histopathology Vol. 36, nº4 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-286
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127106
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNuclear Factor Erythroides
dc.subjectRelated Factores
dc.subject(NRF2)es
dc.subjectBrain Injuryes
dc.subjectFerroptosis (FPT)es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleTargeting NRF2 to suppress ferroptosis in brain injury
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº4 (2021)