Publication: Effects of octreotide on propylotiouracil-induced goiter in rats: a quantitative evaluation
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Date
1998
Authors
Pawlikowski, M. ; Zielinski, K. ; Slowinska-Klencka, D. ; Klencki, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
To evaluate the possible antigoitrogenic
effect of somatostatin, the influence of long-acting
somatostatin analog - octreotide - on experimental goiter
developed in rats treated with propylthiouracil was
examined. Goiter formation was assessed by measurement
of the main histological compartments of the
thyroid as well as by morphometric analysis of the
vascularization and blood supply of the gland. Although
treatment with octreotide did not prevent the goiter
formation, it clearly reduced blood supply and vascularization
of the thyroid and counteracted propylthiouracil-
induced increase in the relative volume of
follicular epithelium. To conclude, the somatostatin
analog - octreotide - is effective in reduction of goiter
vascularisation. This finding provides a rationale for the
clinical trials of the treatment of hypewascular goiter by
somatostatin analogs.
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