Publication: Progress in histopathologic and pathogenetic research in a retinitis pigmentosa model
Authors
Liu, Xin ; Zhang, Yan Zhang ; He, Yuxi ; Zhao, Jinsong ; Su, Guanfang
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Publisher
Universidad de Murcia. Servicio de publicaciones
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DOI
10.14670/HH-11-596
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info:eu-repo/semantics/article
Description
Abstract
Retinitis pigmentosa is a major cause of
visual impairment and blindness, affecting millions of
people worldwide. The mechanisms of and effective
treatments for the disease, however, remain to be further
investigated. The Royal College of Surgeons rat is one
of the most widely used animal models for the study of
retinal degeneration diseases. The mutation in the mer
tyrosine kinase proto-oncogene of this model leads to
deficient phagocytosis in the retinal pigment epithelium
cells and the accumulation of photoreceptor out
segments in the subretinal space, ultimately resulting in
retinal degeneration. The retina begins to change as early
as 17 days after birth and becomes gradually thinner
with the death and remodeling of cells and blood vessels.
Retinal cell apoptosis plays a dominant role in this
degeneration, with some cells being activated by the
secondary alterations of the retinal neurotransmitter and
other related factors.
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Citation
Histology and Histopathology, vol. 30, nĀŗ 7, (2015)
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