Publication: Gap junction channel: new roles in disease
Authors
Donaldson, P. ; Ecker, R. ; Green, C. ; Kistler, J.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The irnportance of intercellular communication
to complex cellular processes such as development,
differentiation, growth, propagation of electrical
impulses and diffusional feeding has long been
appreciated. The realization that intercellular communication
is mediated by gap junction channels, which are
in turn comprised of a diverse family of proteins called
the connexins, has provided new tools and avenues for
studying the role of intercellular communication in these
important cellular processes. The identification of
different connexin isoforms has not only enabled the
development of specific reagents to study connexin
expression patterns, but has also allowed the functional
properties of the different connexin isoforms and how
they interact with each other, to be explored.
Increasingly, the knowledge gained from studying
connexin diversity is being used to investigate the role
played by gap junction channels in a number of diseases.
In this article we highlight selected cases where gap
junction channels have been shown or are believed to be
directly involved in the disease process.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.