Publication: lmmunohistochemical demonstration of secretory IgA in human urothelium
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Date
1995
Authors
Sirigu, P. ; Perra, M. T. ; Turno, F. ; Usai, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The mucosal surface of the human
urothelium represents a very large exposure area to
exogeoous agents, including potentially harmful
microorganisms. Male human urothelium was treated for
the immunohistochemical demonstration of secretory
IgA (sIgA) in order to verify its own possible
antimicrobial properties. An intense immunoreactivity
for sIgA was observed in the apical cells of the urethral
and vesical epithelia. The ureteric epithelium, at the
lumina1 surface, showed discontinuous areas of less
dense or completely absent reaction product. A less
intense immunoreactivity was observed in the pelvic
apical epithelial cells. The results suggest that sIgA play
a prominent role in the local defence mechanisms of the
lower urinary tract against ascending infectqns, whereas
in the upper urinary tract the immuno-specific local
defences seem reduced.
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Citation
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