Publication: An ultratructural and immunohistochemical study of extracellular matrix in meningiomas
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Date
1990
Authors
Hisashi Nitta ; Tetsumori Yamashima ; Junkoh Yamashita ; Toshihiko Kubota
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Extracellular matrix of meningiomas was
studied by light and electron microscopy with the aid of
immunohistochemical techniques. Special attention was
paid to the distribution of type 1,111, IV, V collagens and
laminin with a comparison between meningothelial and
fibroblastic types. Connective tissue fibers and basement
membrane were not found among the tumor cells in the
meningothelial type, but were found in the fibroblastic
type. The immunolocalizations were consistently
demonstrated extracellularly, but were not within the
cytoplasm. Type 1, 111 and V collagens were usually
demonstrated in the fibrous septum in the meningothelial
type, while they were localized among the tumor cells in
the fibroblastic type. Furthermore, type IV collagen and
laminin were demonstrated within the vascular walls or
around the syncytium in the meningothelial type, while
they were localized among the tumor cells in the
fibroblastic type. In both types the expression of type IV
collagen and laminin was closely related to the distribution
of basement membrane. Although meningothelial and
fibroblastic meningiomas showed quite different
distribution of extracellular matrices, the profile of
collagen types expressed by these two basic types was
essentially the same. The cellular derivation of
meningiomas was discussed with particular attention to
the structure of human arachnoid villi and meninges.
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