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Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development

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dc.contributor.authorGarcía López, Margarita
dc.contributor.authorAbellán, Antonio
dc.contributor.authorRubenstein, John L. R.
dc.contributor.authorPuelles, Luis
dc.contributor.authorMedina, Loreta
dc.contributor.authorLegaz Pérez, Isabel
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-07-12T08:42:55Z
dc.date.available2024-07-12T08:42:55Z
dc.date.issued2007-11-07
dc.description© 2007 Wiley-Liss, Inc. This document is the Published version of a Published Work that appeared in final form in Journal of Comparative Neurology. To access the final edited and published work see https://doi.org/10.1002/cne.21524
dc.description.abstractThe amygdala controls emotional and social behavior and regulates instinctive reflexes such as defense and reproduction by way of descending projections to the hypothalamus and brainstem. The descending amygdalar projections are suggested to show a cortico-striato-pallidal organization similar to that of the basal ganglia (Swanson [2000] Brain Res 886:113–164). To test this model we investigated the embryological origin and molecular properties of the mouse centromedial and extended amygdalar subdivisions, which constitute major sources of descending projections. We analyzed the distribution of key regulatory genes that show restricted expression patterns within the subpallium (Dlx5, Nkx2.1, Lhx6, Lhx7/8, Lhx9, Shh, and Gbx1), as well as genes considered markers for specific subpallial neuronal subpopulations. Our results indicate that most of the centromedial and extended amygdala is formed by cells derived from multiple subpallial subdivisions. Contrary to a previous suggestion, only the central—but not the medial—amygdala derives from the lateral ganglionic eminence and has striatal-like features. The medial amygdala and a large part of the extended amygdala (including the bed nucleus of the stria terminalis) consist of subdivisions or cell groups that derive from subpallial, pallial (ventral pallium), or extratelencephalic progenitor domains. The subpallial part includes derivatives from the medial ganglionic eminence, the anterior peduncular area, and possibly a novel subdivision, called here commissural preoptic area, located at the base of the septum and related to the anterior commissure. Our study provides a molecular and morphological foundation for understanding the complex embryonic origins and adult organization of the centromedial and extended amygdala.es
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dc.format.extent29es
dc.identifier.citationJournal of Comparative Neurology, 2007, Vol. 506, Issue 1, pp. 46-74
dc.identifier.doihttps://doi.org/10.1002/cne.21524
dc.identifier.issnPrint: 0021-9967
dc.identifier.issnElectronic: 1096-9861
dc.identifier.urihttp://hdl.handle.net/10201/143057
dc.languageenges
dc.publisherWiley
dc.relationSpanish Ministry of Science and Technology (DGICYTFEDER); Grant numbers: BFI2003-06453-C02-02, BFU2006-14804-C02-02/ BFI (to L.M.); BFU2005-09378, C01-C02/BFI (to L.P.); Grant sponsor: Health Institute Carlos III-FEDER; Grant number: 01/0057-02 (to L.M.); Grant sponsor: Se´neca Foundation; Grant number: PB/50/FS/02 (to L.M.); Grant sponsor: Nina Ireland (to J.L.R.R.); Grant sponsor: National Institute of Mental Health (NIMH); Grant number: K05 MH065670 (to J.L.R.R.).es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/cne.21524
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSubpallial amygdala
dc.subjectVentral pallial amygdala
dc.subjectBed nucleus of the stria terminalis
dc.subjectPreoptic region
dc.subjectSeptum
dc.subjectAnterior entopeduncular area
dc.subjectTranscription factors
dc.titleHistogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during developmentes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationb83b4b59-2d61-40f0-9108-5c6a6d158295
relation.isAuthorOfPublication.latestForDiscoveryb83b4b59-2d61-40f0-9108-5c6a6d158295
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