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Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon

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dc.contributor.authorPeñin Franch, Alejandro
dc.contributor.authorGarcía Vidal, José Antonio
dc.contributor.authorMartínez Cáceres, Carlos Manuel
dc.contributor.authorEscolar Reina, Pilar
dc.contributor.author Martínez Ojeda, Rosa M.
dc.contributor.authorGómez, Ana I.
dc.contributor.authorBueno García, Juan Manuel
dc.contributor.author Minaya-Muñoz, Francisco
dc.contributor.authorValera-Garrido, Fermín
dc.contributor.authorEscolar Reina, Pilar
dc.contributor.authorBueno García, Juan Manuel
dc.contributor.authorMedina i Mirapeix, Francesc
dc.contributor.departmentFisioterapia
dc.date.accessioned2025-01-20T12:02:35Z
dc.date.available2025-01-20T12:02:35Z
dc.date.copyright© 2022, Peñin-Franch et al.
dc.date.issued2022-02-24
dc.description.abstractThe NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produce a degenerative condition that impairs tissue healing and which therefore complicates their clinical management. Percutaneous needle electrolysis consists of the application of a galvanic current and is an emerging treatment for tendinopathies. In the present study, we found that galvanic current activates the NLRP3 inflammasome and induces an inflammatory response that promotes a collagen-mediated regeneration of the tendon in mice. This study establishes the molecular mechanism of percutaneous electrolysis that can be used to treat chronic lesions and describes the beneficial effects of an induced inflammasome-related response.es
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dc.format.extent23es
dc.identifier.citationeLife 11:e73675
dc.identifier.doihttps://doi.org/10.7554/eLife.73675
dc.identifier.eissn2050-084X
dc.identifier.urihttp://hdl.handle.net/10201/148821
dc.languageenges
dc.publishereLife Sciences Publicationses
dc.relationAP-F was supported by MVClinic and Prim. This work was supported by grants to PP from FEDER/Ministerio de Ciencia, Innovación y Universidades – Agencia Estatal de Investigación (grant SAF2017-88276-R and PID2020-116709RB-I00), Fundación Séneca (grants 20859/PI/18 and 21081/PDC/19), and the European Research Council (ERC-2013-CoG grant 614,578 and ERC-2019-PoC grant 899636). Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación supported JMB (grant PID2020-113919RB-I00).es
dc.relation.publisherversionhttps://elifesciences.org/articles/73675es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleGalvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicatione35eed8a-dcb1-427d-b16b-90354bde9aef
relation.isAuthorOfPublication460f1110-b358-474a-9e08-f92fabe4be2b
relation.isAuthorOfPublication45e53b52-9e32-42a5-8a9f-05d7e8adff0c
relation.isAuthorOfPublication.latestForDiscoverye35eed8a-dcb1-427d-b16b-90354bde9aef
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