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Diagnostic and prognostic value of T-cell receptor gamma alternative reading frame protein (TARP) expression in prostate cancer

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dc.contributor.authorFritzsche, Florian R.
dc.contributor.authorStephan, Carsten
dc.contributor.authorGerhardt, Josefine
dc.contributor.authorLein, Michael
dc.contributor.authorHofmann, Irina
dc.contributor.authorJung, Klaus
dc.contributor.authorDietel, Manfred
dc.contributor.authorKristiansen, Glen
dc.date.accessioned2015-10-06T14:08:41Z
dc.date.available2015-10-06T14:08:41Z
dc.date.issued2010
dc.description.abstractT-cell receptor gamma chain alternative reading frame protein (TARP) has recently been proposed as being up-regulated in prostate cancer (PCA). Additionally, TARP has been proposed as a potential therapeutic target for cancer therapy. We analysed the protein expression of TARP in a large well characterised prostate cancer cohort to assess its diagnostic and prognostic value. Methodologically, we constructed a tissue microarray comprising more than 600 PCA cases including matching benign prostate tissue. TARP protein expression was carefully analysed and associated with clinico-pathological parameters, PSA-relapse free survival and expression data of established and proposed diagnostic markers (AMACR, p63, GOLPH2). Our results show that TARP is significantly over-expressed in the vast majority (~85%) of PCA in comparison to non neoplastic prostate tissue. Its expression was associated with conventional markers of unfavourable and more aggressive tumour behaviour. However, a prognostic value of TARP could not be found. The diagnostic value of TARP is limited in comparison to AMACR, p63 or GOLPH2. Since TARP specific immunologic therapy regimen are currently being tested, the high frequency of TARP overexpression in PCA conveys a high potential for a predictive and potentially therapeutic use of this biomarker.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/46507
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 25, nº 6 (2010)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDiagnostic markeres
dc.subjectProstate canceres
dc.subject.other616.6 - Patología del sistema genitourinarioes
dc.titleDiagnostic and prognostic value of T-cell receptor gamma alternative reading frame protein (TARP) expression in prostate canceres
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº6 (2010)