Publication: Diagnostic and prognostic value of
T-cell receptor gamma alternative reading
frame protein (TARP) expression in prostate cancer
Authors
Fritzsche, Florian R. ; Stephan, Carsten ; Gerhardt, Josefine ; Lein, Michael ; Hofmann, Irina ; Jung, Klaus ; Dietel, Manfred ; Kristiansen, Glen
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
T-cell receptor gamma chain alternative
reading frame protein (TARP) has recently been
proposed as being up-regulated in prostate cancer
(PCA). Additionally, TARP has been proposed as a
potential therapeutic target for cancer therapy. We
analysed the protein expression of TARP in a large well
characterised prostate cancer cohort to assess its
diagnostic and prognostic value. Methodologically, we
constructed a tissue microarray comprising more than
600 PCA cases including matching benign prostate
tissue. TARP protein expression was carefully analysed
and associated with clinico-pathological parameters,
PSA-relapse free survival and expression data of
established and proposed diagnostic markers (AMACR,
p63, GOLPH2). Our results show that TARP is
significantly over-expressed in the vast majority (~85%)
of PCA in comparison to non neoplastic prostate tissue.
Its expression was associated with conventional markers
of unfavourable and more aggressive tumour behaviour.
However, a prognostic value of TARP could not be
found. The diagnostic value of TARP is limited in
comparison to AMACR, p63 or GOLPH2. Since TARP
specific immunologic therapy regimen are currently
being tested, the high frequency of TARP overexpression
in PCA conveys a high potential for a
predictive and potentially therapeutic use of this
biomarker.
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