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Characterization of the early pathology of cochlear stereocilia in four inbred mouse strains with progressive hearing loss

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dc.contributor.authorLiu, Xiang
dc.contributor.authorXie, Yi
dc.contributor.authorHuang, Shanshan
dc.contributor.authorXu, Ang
dc.contributor.authorZhao, Mengmeng
dc.contributor.authorKang, Xiaoxia
dc.contributor.authorYan, Aiwei
dc.contributor.authorLi, Ping
dc.contributor.authorJin, Changzhu
dc.contributor.authorHan, Fengchan
dc.date.accessioned2022-07-05T09:04:28Z
dc.date.available2022-07-05T09:04:28Z
dc.date.issued2019
dc.description.abstractObjective. Inbred strains of mice offer promising models for understanding the genetic basis of age-related hearing loss (AHL). NOD/LtJ, A/J, DBA/2J and C57BL/6J mice are classical models of age-related hearing loss and exhibit early onset of pathology of AHL. This study was carried out to characterize the early pathology of cochlear stereocilia in the four mouse strains with age-related hearing loss. Methods. The structural features of stereocilia in NOD/LtJ, A/J, DBA/2J and C57BL/6J mice were observed by scanning electron microscopy (SEM) at age of 2, 4, 6 or 8, and 10 or 12 weeks. Meanwhile, auditoryevoked brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) amplitudes of the mice were measured at various intervals (3, 4, 6, 8, 10 and 12 weeks of age). Results. The ABR thresholds in NOD/LtJ, A/J and DBA/2J mice increased with age from 3 to 12 weeks. DPOAE amplitudes in NOD/LtJ, A/J, DBA/2J mice were very low at 4 weeks and became negative at 8 weeks at f2 frequency of 17 672 Hz. In addition to the progressive hearing loss, the four mouse strains displayed early onset (at 2 weeks of age) and progressive degeneration of stereocilia in hair cells. Conclusion. Early degeneration of stereocilia contributes to the functional impairment of hair cells and hearing loss in NOD/LtJ, A/J, DBA/2J and C57BL/6J mice.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.doiDOI: 10.14670/HH-18-086
dc.identifier.eisbnHistology and Histopathology, Vol.34, nÂş7, (2019)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/122109
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAge-related hearing losses
dc.subjectMouse modeles
dc.subjectHair cellses
dc.subjectStereociliaes
dc.subjectScanning electron microscopees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleCharacterization of the early pathology of cochlear stereocilia in four inbred mouse strains with progressive hearing losses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.34, nÂş7 (2019)