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Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score

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dc.contributor.authorBernabeu Mora, Roberto
dc.contributor.authorOliveira Sousa, Silvana Loana de
dc.contributor.authorMedina i Mirapeix, Francesc
dc.contributor.authorGacto Sánchez, Mariano Luis
dc.contributor.departmentFisioterapia
dc.date.accessioned2026-02-23T08:55:29Z
dc.date.available2026-02-23T08:55:29Z
dc.date.copyright© 2024 The Authors
dc.date.issued2024-07-01
dc.description.abstractBackground: The objective of this study was to determine whether the concomitant presence of poor health status (COPD Assessment Test, CAT ≥ 10 points) and low exercise tolerance (6-Minute Walking Test, 6MWT < 350 m) is associated with worse clinical characteristics in patients with COPD. In addition, we aimed to develop a readily applicable diagnostic model to discriminate COPD patients with these conditions. Methods: A cross-sectional multicenter study involving 208 stable COPD patients (FEV1/FVC < 0.7, smoking history of at least 10 pack-years, and chronic respiratory symptoms) was carried out. The outcome measures were the 6MWT, CAT score, 5-repetition sit-to-stand test (5STS) and modified Medical Research Council Dyspnea Scale (mMRC). Patients were categorized into three groups: no condition (6MWT ≥ 350 m and CAT < 10 points), one condition (6MWT < 350 m or CAT ≥ 10 points), and both conditions (6MWT < 350 m and CAT ≥ 10 points). Results: A total of 26 patients (12,5%) presented both conditions. These patients experienced a higher degree of dyspnea (p = 0.001), smoking pack-years (p = 0.011), severe obstruction (p = 0.006), and time on 5STS (p = 0.001). The probability of having both conditions directly increased with the time spent on the 5STS (β=0.188; p = 0.010) and the degree of dyspnea (β=1.920; p < 0.001) (R2=0.413). The scoring system, using the 5STS and dyspnea as surrogate measures, demonstrated adequate calibration between the predicted and observed risk (linear R2=0.852). Conclusions: COPD patients with concurrent conditions have worse clinical status. The diagnostic model developed to discriminate these patients shows good internal validation.
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dc.identifier.citationBernabéu-Mora R, Oliveira-Sousa SL, Medina-Mirapeix F, Gacto-Sánchez M; Group of Investigation SAQ_COPD. Identifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score. Eur J Intern Med. 2024;125:51-56.
dc.identifier.doihttps://doi.org/10.1016/j.ejim.2024.03.032
dc.identifier.eissn1879-0828
dc.identifier.issn0953-6205
dc.identifier.urihttp://hdl.handle.net/10201/209782
dc.languageeng
dc.publisherElsevier
dc.relationSin financiación externa a la Universidad
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0953620524001407?via%3Dihub
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChronic obstructive pulmonary disease
dc.subjectHealth status
dc.subjectExercise tolerance
dc.subjectDyspnea
dc.subject.odsObjetivo 3: Salud
dc.titleIdentifying COPD patients with poor health status and low exercise tolerance through the five-repetition sit-to-stand test and modified Medical Research Council Dyspnea Score
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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