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Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding ß-amyloid deposits in the rat brain

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dc.contributor.authorSong, Y.es
dc.contributor.authorMorikawa, S.es
dc.contributor.authorMorita, M.
dc.contributor.authorInubushi, T.
dc.contributor.authorTakada, T.
dc.contributor.authorTorii, R.
dc.contributor.authorKitamura, Y.
dc.contributor.authorTaniguchi, T.
dc.contributor.authorTooyama, I.
dc.date.accessioned2011-06-30T12:03:10Z
dc.date.available2011-06-30T12:03:10Z
dc.date.issued2006
dc.description.abstractThe therapeutic use of microglial cells has recently received some attention for the treatment of Alzheimer disease (AD), but few non-invasive techniques exist for monitoring the cells after administration. Here we present a magnetic resonance imaging (MRI) technique for tracking microglia injected intra-arterially in vivo. We micro-injected Aß42 into the left hippocampus and saline into the right hippocampus of rats. We then administered microglia, which were labeled with enhanced green fluorescent protein (EGFP) gene and Resovist, into the carotid artery. After monitoring exogenously administered microglia using MRI, we compared the MR images and the histochemical localization of administered microglia. MRI revealed clear signal changes attributable to Resovist-containing microglia in Aß-injected areas. Histochemistry demonstrated that EGFP-positive microglia accumulated around Aß deposits and internalized the peptide. This study demonstrates the usefulness of MRI for non-invasive monitoring of exogenous microglia, and suggests a promising future for microglia/macrophages as therapeutic tools for AD.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22680
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAlzheimer’s diseasees
dc.subjectMicrogliaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nerviosoes
dc.titleComparison of MR images and histochemical localization of intra-arterially administered microglia surrounding ß-amyloid deposits in the rat braines
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.21, nº 7 (2006)