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Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes

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dc.contributor.authorMori, F.es
dc.contributor.authorPiro, F.R.es
dc.contributor.authorDella Rocca, C.
dc.contributor.authorMesiti, G.
dc.contributor.authorGiampaoli, S.
dc.contributor.authorSilvestre, G.
dc.contributor.authorLazzaro, D.
dc.date.accessioned2012-05-21T12:08:19Z
dc.date.available2012-05-21T12:08:19Z
dc.date.issued2007
dc.description.abstractIn the evolution of colon rectal cancer (CRC) the imbalance between cell proliferation and apoptosis is considered one of the prominent causes of tumor induction and/or progression. In order to establish the role of anti apoptotic proteins in colon cancer development, we studied with immunohistochemical techniques the expression of Survivin in a mouse model of colon carcinogenesis induced by 1,2-dimethylhydrazine treatment. In this mouse model Survivin was over-expressed during tumor development, showing a distribution mimicking that described in the correspondent human malignancies. We also correlated Survivin distribution with COX-2 and ß-Catenin expression patterns. The co-localization of COX-2/ß-Catenin/Survivin in the same epithelial cells in tumor samples lends credence to possible in vivo regulatory effects of COX-2 and ß- Catenin on the intracellular Survivin levels in mouse and human colon cancer.es
dc.formatapplication/pdfes
dc.format.extent17es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27533
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectColon canceres
dc.subjectMousees
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleSurvivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocyteses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº 1 (2007)