Publication: Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes
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Date
2007
Authors
Mori, F. ; Piro, F.R. ; Della Rocca, C. ; Mesiti, G. ; Giampaoli, S. ; Silvestre, G. ; Lazzaro, D.
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Publisher
Murcia : F. Hernández
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Description
Abstract
In the evolution of colon rectal cancer (CRC)
the imbalance between cell proliferation and apoptosis is
considered one of the prominent causes of tumor
induction and/or progression. In order to establish the
role of anti apoptotic proteins in colon cancer
development, we studied with immunohistochemical
techniques the expression of Survivin in a mouse model
of colon carcinogenesis induced by 1,2-dimethylhydrazine
treatment.
In this mouse model Survivin was over-expressed
during tumor development, showing a distribution
mimicking that described in the correspondent human
malignancies. We also correlated Survivin distribution
with COX-2 and ß-Catenin expression patterns.
The co-localization of COX-2/ß-Catenin/Survivin in
the same epithelial cells in tumor samples lends credence
to possible in vivo regulatory effects of COX-2 and ß-
Catenin on the intracellular Survivin levels in mouse and
human colon cancer.
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