Publication: The role of peritoneal macrophages in Endometriosis.
Authors
Ramírez Pavez, Tamara N. ; Martínez Esparza, M. ; Ruiz Alcaraz, Antonio J. ; Marín Sánchez, Pilar ; Machado Linde, Francisco ; García Peñarrubia, Pilar
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Publisher
MDPI
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Description
© 2021 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/10.3390/ijms221910792
Abstract
Endometriosis is an estrogen-dependent gynecological disorder, defined as the growth of
endometrial stromal cells and glands at extrauterine sites. Endometriotic lesions are more frequently
located into the abdominal cavity, although they can also be implanted in distant places. Among its
etiological factors, the presence of immune dysregulation occupies a prominent place, pointing out
the beneficial and harmful outcomes of macrophages in the pathogenesis of this disease. Macrophages
are tissue-resident cells that connect innate and adaptive immunity, playing a key role in maintaining
local homeostasis in healthy conditions and being critical in the development and sustainment of
many inflammatory diseases. Macrophages accumulate in the peritoneal cavity of women with
endometriosis, but their ability to clear migrated endometrial fragments seems to be inefficient.
Hence, the characteristics of the peritoneal immune system in endometriosis must be further studied
to facilitate the search for new diagnostic and therapeutic tools. In this review, we summarize recent
relevant advances obtained in both mouse, as the main animal model used to study endometriosis,
and human, focusing on peritoneal macrophages obtained from endometriotic patients and healthy
donors, under the perspective of its future clinical translation to the role that these cells play on this
pathology.
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