Publication: Analysis of the anti-inflammatory potential of Brassica bioactive compounds in a human macrophage-like cell model derived from HL-60 cells
Authors
Ruiz Alcaraz, Antonio José ; Martínez Sánchez, María Antonia ; García Peñarrubia, Pilar ; Martínez Esparza, M. ; Ramos Molina, Bruno ; Moreno, Diego A.
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Publisher
Elsevier
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Description
© 2022 The Authors. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Published version of a Published Work that appeared in final form in Biomedicine and Pharmacotherapy. To access the final edited and published work see https://doi.org/10.1016/j.biopha.2022.112804
Abstract
Background: Chronic inflammatory diseases are major causes of global morbidity and mortality. Acute inflammation
is meant to protect the body against foreign agents, but it also plays a major role in tissue repairment.
Several mediators are involved in this process, including pro-inflammatory cytokines produced by macrophages.
Occasionally, if the inflammatory response is not resolved, the acute inflammatory process can evolve into a
chronic inflammation. Natural compounds from vegetables are considered as an important source of active
agents with potential to treat or prevent inflammatory related pathologies and could be used as an alternative of
the therapeutic agents currently in use, such as non-steroidal anti-inflammatory drugs (NSAIDs), which present
several side effects.
Methods: In this research work we evaluated in vitro the anti-inflammatory activity of a series of ten phytochemicals
present in Brassica, measured as the potential of those compounds to reduce the production of key proinflammatory
cytokines (TNF-α, IL-6 and IL-1β) by a human macrophage-like cell model of HL-60 cells
Results: Most of the tested phytochemicals (including the most representative bioactive molecules of the major
classes of compounds present in cruciferous foods such as glucosinolates, isothiocyanates, hydroxycinnamic
acids, flavonols and anthocyanins) demonstrated significant anti-inflammatory activity at micromolar level in
the absence of cytotoxic effects in this human macrophage-like cell model.
Conclusion: These data confirm that phytochemicals commonly obtained from Brassica may be potential therapeutic
leads to treat or prevent human chronic inflammation and related diseases.
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