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Oxidized regenerated cellulose does not prevent the formation of experimental postoperative perineural fibrosis assessed by digital analysis

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dc.contributor.authorHernández Cortés, Pedro
dc.contributor.authorPeregrina, Magdalena
dc.contributor.authorAneiros Fernández, José
dc.contributor.authorTassi, Mohamed
dc.contributor.authorPajares López, Miguel
dc.contributor.authorToledo, Miguel
dc.contributor.authorO’Valle, Francisco
dc.date.accessioned2015-10-06T14:23:03Z
dc.date.available2015-10-06T14:23:03Z
dc.date.issued2010
dc.description.abstractIntroduction: It is difficult to prevent and treat intra- and peri-neural fibrosis after peripheral nerve surgery. Many authors have attempted to develop and verify the effectiveness of substances to decrease the formation of adherences in different tissues. Material and Methods: this study aimed to assess the effectiveness of a barrier of oxidized regenerated cellulose (ORC) to reduce adherence and perineural fibrosis in a model of surgical perineural induced fibrosis in rat sciatic nerve in 40 rats. After tissue aggression, the nerve of the right rear limb was wrapped in ORC and the left limb served as control. Animals were killed at 3 and 6 weeks, and nerves and muscle mass were extracted en bloc. Connective tissue was quantified by conventional histopathological techniques and Fibrosis HR® automatic image analysis. Results: No significant differences were found in intra- or peri-neural induced fibrosis between control nerves (6.88% and 8.90%, respectively) and treated nerves (6.57% and 9.90%) at 3 or 6 weeks (10.41% and 12.51% in controls; 11.85% and 15.72% in treated nerves). Inflammatory phenomena and granulomatous reactions were more frequent in treated animals. Conclusions: ORC conferred no advantage in prevention of nerve fibrosis and might have interfered with healing.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/46508
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and histopathology, Vol. 25, nº 6 (2010)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectFibrosises
dc.subjectRatses
dc.subject.other616.7 - Patología de los órganos de la locomoción. Sistema locomotor y esqueléticoes
dc.titleOxidized regenerated cellulose does not prevent the formation of experimental postoperative perineural fibrosis assessed by digital analysises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº6 (2010)