Publication: Oxidized regenerated cellulose does not
prevent the formation of experimental postoperative
perineural fibrosis assessed by digital analysis
Authors
Hernández Cortés, Pedro ; Peregrina, Magdalena ; Aneiros Fernández, José ; Tassi, Mohamed ; Pajares López, Miguel ; Toledo, Miguel ; O’Valle, Francisco
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Introduction: It is difficult to prevent and
treat intra- and peri-neural fibrosis after peripheral nerve
surgery. Many authors have attempted to develop and
verify the effectiveness of substances to decrease the
formation of adherences in different tissues. Material
and Methods: this study aimed to assess the
effectiveness of a barrier of oxidized regenerated
cellulose (ORC) to reduce adherence and perineural
fibrosis in a model of surgical perineural induced
fibrosis in rat sciatic nerve in 40 rats. After tissue
aggression, the nerve of the right rear limb was wrapped
in ORC and the left limb served as control. Animals
were killed at 3 and 6 weeks, and nerves and muscle
mass were extracted en bloc. Connective tissue was
quantified by conventional histopathological techniques
and Fibrosis HR® automatic image analysis. Results: No
significant differences were found in intra- or peri-neural
induced fibrosis between control nerves (6.88% and
8.90%, respectively) and treated nerves (6.57% and
9.90%) at 3 or 6 weeks (10.41% and 12.51% in controls;
11.85% and 15.72% in treated nerves). Inflammatory
phenomena and granulomatous reactions were more
frequent in treated animals. Conclusions: ORC conferred
no advantage in prevention of nerve fibrosis and might
have interfered with healing.
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