Resveratrol lacks antifungal activity against Candida albicans.

Collado-González,  Mar; Guirao-Abad, José Pedro; Sánchez-Fresneda Pinto, Ruth; Belchí Navarro, Sarai; Argüelles Ordóñez, Juan Carlos

Publication:
Resveratrol lacks antifungal activity against Candida albicans.

dc.contributor.author	Collado-González, Mar
dc.contributor.author	Guirao-Abad, José Pedro
dc.contributor.author	Sánchez-Fresneda Pinto, Ruth
dc.contributor.author	Belchí Navarro, Sarai
dc.contributor.author	Argüelles Ordóñez, Juan Carlos
dc.contributor.department	Genética y Microbiología
dc.date.accessioned	2025-09-25T06:53:31Z
dc.date.available	2025-09-25T06:53:31Z
dc.date.copyright	© 2012
dc.date.issued	2012-03-30
dc.description.abstract	The putative candicidal activity of resveratrol is currently a matter of controversy. Here, the antifungal activity as well as the antioxidant response of resveratrol against Candida albicans, have been tested in a set of strains with a well-established genetic background At the doses usually employed in antifungal tests (10–40 lg/ml), resveratrol has no effect on the exponential growth of the C. albicans CAI.4 strain, a tenfold increase (400 lg/ml) was required in order to record a certain degree of cell killing, which was negligible in comparison with the strong antifungal effect caused by the addition of amphotericin B (5 lg/ml). An identical pattern was recorded in the prototrophic strains of C. albicans SC5314 and RM-100, whereas the oxidative sensitive trehalose-deficient mutant (tps1/tps1 strain) was totally refractory to the presence of resveratrol. In turn, the serum-induced yeast-to-hypha transition remained unaffected upon addition of different concentrations of resveratrol. Determination of endogenous trehalose and catalase activity, two antioxidant markers in C. albicans; revealed no significant changes in their basal contents induced by resveratrol. Collectively, our results seem to dismiss a main antifungal role as well as the therapeutic application of resveratrol against the infections caused by C. albicans.
dc.format	application/pdf
dc.format.extent	6
dc.identifier.citation	World Journal of Microbiology and Biotechnology 28, 2441–2446 (2012)
dc.identifier.doi	https://doi.org/10.1007/s11274-012-1042-1
dc.identifier.eissn	1573-0972
dc.identifier.issn	0959-3993
dc.identifier.uri	http://hdl.handle.net/10201/159889
dc.language	eng
dc.publisher	Springer
dc.relation	We are indebted to Dr. M. A. Pedreño (University of Murcia) for ther kind provision of resveratrol, critical reading of the manuscript and useful suggestions. The experimental work was supported in part by grant BIO-BMC 06/01-0003 from Dirección General de Investigación (Comunidad de Murcia, Spain), We are also indebted to the financial contract provided by Cespa, S.A.
dc.relation.publisherversion	https://link.springer.com/article/10.1007/s11274-012-1042-1
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject.ods	No relacionado con ningún objetivo de desarrollo sostenible
dc.title	Resveratrol lacks antifungal activity against Candida albicans.
dc.type	info:eu-repo/semantics/article
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