Publication: Structural changes in glomeruli and proteinuria in
streptozotocin diabetic rats
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Date
1989
Authors
Al-Awadi, Farida M. ; Al-Adnani, M. S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In streptozotocin induced diabetes in rats,
excretion of urinary protein fractions were studied in
relation to structural changes in the renal glomeruli,
using light and transmission electron microscopy. After
six weeks of induced diabetes only 01 and B2 plasma
globulins were significantly elevated. The amount of
excreted proteins and degree of glomerular changes were
not proportional. In the initial stages (1-2 weeks)
glomerular structural changes were very mild and were
accompanied by significantly elevated proteinuria. This
progressed (4-8 weeks) to moderate to prominent
structural changes with intermittent proteinuria except
for the fractions 01 & B2 which were elevated throughout
the duration of the experiment. The amount of
proteinuria was not proportional to changes in the
plasma protein levels.
The following conclusions may be made:
1) The mild early glomerular abnormalities seem to be
mainly due to acute metabolic disturbances.
2) An early indication of diabetic nephropathy is
provided not only by albuminuria, but may also be an
elevated excretion of betaglobulin fractions.
3) Decrease of albuminuria in the later stages of diabetes
may be related to the deposition of albumin as a
basement membrane - like material in the mesangium.
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